A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes
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چکیده
منابع مشابه
Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model
PURPOSE Torsades de pointes (TdP) tachycardias are triggered, polymorphic ventricular arrhythmias arising from early afterdepolarizations (EADs) and increased dispersion of repolarization. Ranolazine is a new agent which reduces pathologically elevated late INa but also IKr . Aim of this study was to evaluate the effects of ranolazine in a validated isolated Langendorff-perfused rabbit heart mo...
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L'intervalle de temps variable existante entre le debut du traitement par la prenylamine et la survenu de toisade de pointe et d'autre oart la raretee de· telle camplication est considere par les auteurs c0mme une indice de !'intervention de d'autres facteurs, parmie Jes quelles, la perturbation electrolytique doit jouer le role principal.
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A dog model of torsades de pointes (TdP) was developed. Twenty 18-30-kg dogs had cardiopulmonary bypass instituted to maintain stable temperature, perfusion pressure and oxygenation. Quinidine, 30 mg/kg, was then administered and burst ventricular pacing was used to induce arrhythmias. The left anterior descending coronary artery was occluded for 15 minutes and repeat pacing studies were perfor...
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Torsade de pointes (Tdp) is a polymorphic ventricular tachycardia (VT) in which the axis of the QRS complex changes direction after a certain number of complexes as if the complex rotated around the baseline. Tdp is usually associated with QT prolongation, and dispersion of ventricular repolarlization (DR). Experimental models of tdp are usually associated with induction of early after depolari...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2006
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706894